BIF501 Solved Paper Updated 2022 Page 127

MID TERM

Quiz No.1

1. RNA DNA RNA protein is a process occurs in. ______________________________retroviruses
2. Systic fibrosis gene is found on chromosome number.__________________________________7
3. Bypass is a type of ………algorithm._________________________________Branch and Bound
4. Gel electrophoresis may be used to measured ……..of restriction fragments._____________SIZE
5. Consensus score is defined as….._______________________________________score(s.DNA)
6. Protein is extracted from ____________________________________________________mRNA
7. Restriction enzyme break DNA molecules at….. _________________________specific location
8. Motifs are found in…… __________________________________________________Promoters
9. Pre-order algorithm is a ….. _______________________________________________Recursive
10. Genome rearrangement result in change of gene…________________________________order
11. Regulatory motif are generally found in…. ________________________promoter region of DNA
12. Median string problem is one of the ways to find…________________________________motifs
13. Next vertex algorithm provides as an output…. _________________________________efficient
14. We get the best and more occurring residue sequence called…. ________consensus sequence

15. Chimera is used for. _______________________________________Visualization and editing

16. Motifs facilitate for binding ._______________________________________transcription factor
17. Next vertex algorithm provides as an output… ______________________________next subtree
18. Waardenburg’s syndrome is a genetic disorder in.._______________________________ human
19. Expressed Sequence Tags (EST) are ______ copies of cell’s mRNA sequences.__ _______Cdna
20. which one is not a model organism-------______________________________________elephant
21. The study of all of a person's gene is known as ....._____________________________genomics
22. In RNA uracil pairs with -------- ______________________________________________Adenine
23. Human Genome Project- _____________________________3 billion-nucleotide sequence
24. In human genome project total _______ bases were sequenced.______ _________3.4 billion bp
25. in RNA molecule thymine is replaced by--------- ___________________________________Uracil
26. ________ Is an example of protein database__________________________________unitprot
27. Identification of drugs through genomic study is known as______________ Pharmacogenomics
28. We get the best and more occurring residual sequence called as_______ Consensus sequence
29. which one is a nucleotide database......._________________________________________EMBL
30. Large portion of Eukaryotic Genome contain _______. ______________Transposable elements
31. BLAST program is used in__________________________________________ DNA sequencing
32. Intron Starts at ____ end as _____.______________________________________ 5’ end as GT
33. microsatellites are found in----------_________________________________________Telemores
34. Microsatellites are ______ base long._____________________________________________ 2-6
35. Nucleotide in RNA are joined by ______._____________________ 3’ – 5’ phosphodiester bond
36. A UTR is part of ____________________________________________________________ Exon
37. Translation is the _______. __________________Synthesis of protein from a mRNA template
38. GeneBank is now under______________________________________________________ NCBI
39. _________ are useful markers for genetic analysis and evolutionary studies.______Minisatellites
40. jump from one location to another faster than chromosome replicate------Transposable elements
41. the size of hemophilus influenzae geome is--------___________________________1.8 million bp
42. ______ use actual distances usually measured in number of base pairs.________ Physical maps
43. Which one is the basic step____________________________________________Transcription
44. Exonic region contain only ……….of total DNA______________________________________2%
45. RNA –DNA—RNA –protein is process occur in______________________________Retroviruses
46. Motif facilitate for binding_______________________________________Transcription Factors
47. Median string problem in one of the ways to find ___________________________________Motif
48. Simple Motif Search Algorithm is based on___________________________ Branch and Bound
49. Protein is extracted from_____________________________________________________mRNA
50. Bypass is a type of ……………….algorithm __________________________Branch and Bound
51. Systic fibrosis gene is found on chromosome number_________________________________7
52. Consensus score is defined as_________________________________________Score (s,DNA)
53. Exception to the central dogma comes after the discovery of __________________Retroviruses
54. Next vertex algorthim provides as an output___________________________________Efficient
55. Chimera is used for_________________________________________Visualization and Editing
56. Gene rearrangement result in change of gene ____________________________________order
57. Regulatory motif are generally found in __________________________Promoter region of DNA
58. Gel electrophoresis may be used to measured ……..of restriction fragment ______________Size
59. Restriction enzyme break DNA molecule at _____________________________Specific location
60. Motifs are found in ________________________________________________________Protein
61. Pre order algorithm is a __________________________________________________Recursive
62. Genome rearrangement results in change of gene ________________________________order
63. How many reading frames must be considered for a given double-stranded DNA sequence.___six
64. Which one is a start codon_____________________ _______________________________AUG
65. Which one is not a stop codon._________________ ________________________________UAU
66. Three latter code Leu of protein represents___________________________ __________leucine
67. What is a codon?______________ _________Three nucleotides that codes for an amino acid
68. ________ involves recognition of nucleotides in a Genome and determining their precise order _____._________________ _____________________________________Genome Sequencing
69. Plant devote half of their genome to _______________________________. Energy metabolism

Quiz no 3

1. Of the human genome is so called junk DNA____________________________________96-97%
2. The most conserved part of a gene is __________________________________________Exon
3. …….Matrix contains alignment of very similar proteins______________________________PAM1
4. In alignment score tells us about the goodness of an alignment ________________________true
5. To find……. the pattern local alignment procedure is used.______ Conserved sequence pattern
6. In……grid where each entry in the grid looks like a city block____________________ Manhattan
7. To start a V string into a W string we need to have both insertion and deletion in V string_ ___true
8. 96-97% Of the human genome is so called junk DNA_____ ___________________________true
9. To …… a V string into a W string we need to have both insertion and deletion in V string_ ____ _____________________________________________________________________transform
10. LCS restrictive scoring award ………. For match______________________________________1
11. To find conserved sequence the pattern local alignment procedure is used.______________ true
12. We can avoid the mismatch in an alignment by removing of diagonal edges_ _____________true
13. Analyzing the merit of an alignment also mean the corresponding path in the edit graph__ ___true
14. In the ….problem, where we eliminate the operation of substitution__ ____________________ _____________________________________________________ Longest Common sequence
15. In open reading frame of a single genomic sequence …..sequence are in forward direction whereas ….. sequence are reverse direction _______________________________________3,3
16. …..Of the human genome is so called coding sequence _____________________________2-4%
17. ORFs within a single genomic sequence may overlap since there are …… possible reading frames_______________________________________________________________________6
18. The alignment of the strings v (of n characters) and w (of m characters, with m not necessarily the same as n) is a two row matrix___ __________________________________________true
19. To find the conserved sequence pattern Local alignment procedure is used.__ _________ True
20. Eukaryotic gene is called split gene because it is splitted into Exons and Introns_________ True

21.

1. To find the conserved sequence pattern ____ alignment procedure is used.____ local alignmen
2. Each record in databases is called _____________________________________________. files
3. Which of the following is a sub string of “SANFOUNDRY”?________________________ FOUND
4. The size of Transposable elements is ________________________________________. 1-2 kb
5. GDS record of GEO database is for _________________________________________ sample
6. An isofarm is an alternative ________ of a gene______________________________ Transcript
7. Size of MITES (Miniature Inverted repeat TEs) is ______________________________. 400 bp
8. A Genome Sequence is useless without____________________________________ Annotation
9. In Genebank format the start of the sequence is marked by a line containing._______________ //
10. Exons can be predicted within _____ from the information gathered about splice junction.___ ORF
11. TBLASTN is frequently used for ________.__________________ Proteomes to EST databases
12. The resolution genome map is the genomic DNA sequence that can be; _____ highest, physical
13. One centimorgan is defined as ---------- percentage of the total recombination events._________1
14. There are ------- domains of life._______________________________________________ Three
15. Who maintain the gene bank, a nucleotide sequence database---------------? _________________

________________________________ National Centre for Biotechnology Information (NCBI)

16. How does RNA differ from DNA? __________________________________________________ ________________ RNA contain uracil instead of thymine and it is usually single-stranded
17. Which of the following is considered as a start codon? ______________________________ AUG
18. Which of the following statement about tandem repetitive DNA are correct? __________________

______________________________________Tandem means two repeats next to each other

19. The first published genome was ----------___________________________Hemophilus influenza
20. Consensus score is defined as ---------- __________________________________Score (s, DNA)
21. Pre-order algorithm is a _________________________________________________ Recursive
22. PAM matrices are based on --------- of protein evolution. ____________________ DayHoff model
23. Which of the following are the properties of dynamic programming problem?___optimal structure
24. Informatics in health care is known as ----------- _________________________health informatics
25. There are ------- possible stop codon, identification of which is straightforward. ___________Three
26. The retrieval and search tool of the NCBI is ---------. ______________________________ Entrez
27. Each record in database is called -------- __________________________________________ File
28. Exonic region contain only -------- of total DNA.______________________________________2%
29. Which RNA molecule is used to carry genetic information copied from DNA ____________mRNA
30. Gel electrophoresis may be used to measure ------ of restriction fragments._______________ size
31. Which alignment is useful to detect the highly similar sequences. _________ pairwise alignment
32. Nucleic acid contain ------------ ______________________________________________ Adenine
33. Analyzing or comparing entire genome of species is ----------- ____________________Genomics
34. In dynamic programming, the technique of storing the previously calculated values is called------.

__________________________________________________________________Memorization

35. How many chromosomes do human have? _________________________________________46
36. You do a BLAST search on a DNA sequence and it identifies it as exon 1 of certain gene. An exon is --- _____________________A section of eukaryotic gene that is not translated into protein
37. RNAase is a single polypeptide chain of ------- amino acid residues. ____________________ 124
38. Variation between individuals due to single base changes is called---------- ______________SNPs
39. Bypass is a type of --------- algorithm. _______________________________ Branch and bound
40. SWISS PORT is related to -------------________________________ Protein sequence data bank
41. If the query proteome is not available in protein database, then ----------- database may be

searched. _________________________________________________________________ EST

42. Three latter code Leu of protein represents ---------- _____________________________ Leucine
43. Production of RNA from DNA is called ----------_____________________________ Transcription
44. Gene in two organisms that are so similar that they have the same function and evolutionary history are called ------- __________________________________________________Orthology
45. RNA is the genetic material in ----------- ______________________________________________ ___________________________ In some viruses, prokaryotes and rarely in eukaryotes also
46. Minisatellite is ---------- bases long in array of several hundred to thousands kb. ____________ 15
47. Determining the location of and relative distances between genes on a chromosome is known as -

------ _____________________________________________________________Gene mapping

48. The synthesis of polynucleotide chain of mRNA is catalyzed by the enzyme. ___RNA polymerase
49. Genetic map distances are based on the genetic linkage information measured in____________ ________________________________________________________________ Centi-Morgans
50. Which one is not protein data file? ______________________________________________PDB
51. SINES stands for -------- ___________________________Short interspersed nuclear elements
52. A public repository for the archiving and distribution of gene expression data ____________ GEO
53. Gene expression omnibus (GEO) data base has --------- kind of records. ________________ Four
54. How many reading frames must be considered for a given double-stranded DNA sequence.__Six
55. Peptide linkage are formed in between ------- _______________________________Amino acids
56. Which species have more similar proteome with mammalian proteomes? _________ Drosophilla
57. The process of finding relative location of gene on a chromosome is called --_-Genome mapping
58. What is the full form of BLOSUM? __________________________ BLOcks SUbstitution Matrix
59. Satellite DNA is a tandem array of ------------ million bases long. Ans: 100
60. Protein databases are classified on the bases of ------------ Ans: protein structure, sequence

and domain All

61. If RNA polymerase transcribe DNA with the coding strand (non-template) sequence 5 – GGGCATGCA – 3, what would be the resulting RNA sequence (28) Ans: 5 – GGGCUAGCA - 3
62. Transcription is the transfer of genetic information from Ans: DNA to mRNA
63. Following is an eukaryote________________ Yeast